Quick Facts
| Property | Value |
|---|---|
| Category | Mitochondrial-Derived Peptide |
| Risk Level | Experimental |
| Administration | Subcutaneous Injection |
| Typical Frequency | 3× Weekly |
| Estimated Half-Life | Short Plasma Half-Life / Prolonged Metabolic Signaling Discussed |
| Primary Research Interest | Metabolism / Longevity / Exercise Performance |
This material is provided strictly for educational and informational purposes related to peptide research and experimental metabolic compounds. MOTS-c is a biologically active mitochondrial-derived peptide with limited long-term human safety data and incompletely characterized physiological effects. Information presented here should not be interpreted as medical advice, treatment recommendations, or encouragement of unsupervised use.
1. Reconstitution Guide
- Vial Size: 40 mg
- Dilutant Type: BAC Water
- Amount of Dilutant Added: 3 mL
- Final Concentration: 13.33 mg/mL
At this concentration:
• 5 mg = 0.375 mL (37.5 units)
2. Route of Administration
MOTS-c is most commonly discussed as a subcutaneous injectable mitochondrial-derived peptide compound.
- Primary Route: SubQ Injection
- Preferred Timing: Commonly paired with exercise or metabolic-focused protocols
- Administration Notes: Many users associate the compound with exercise performance and metabolic flexibility discussions
3. Typical Research Protocols
- Product Strength: 13.33 mg/mL
- Typical Delivered Amount: 5 mg
- Frequency: 3× per week
- Cycle Length: 8 weeks on / 6 weeks off
- Special Notes: WARNING: THIS PEPTIDE IS VERY FRAGILE. During reconstitution, avoid aggressive handling of the peptide puck. Roll BAC water gently down the side of the vial and avoid vigorous shaking or mixing.
4. Summary
MOTS-c is an experimental mitochondrial-derived peptide researched for its potential effects on metabolism, exercise performance, insulin sensitivity, and longevity-associated signaling pathways.
Interest in MOTS-c has grown rapidly within metabolic health and longevity communities due to its unusual mitochondrial origin and proposed exercise-mimetic effects.
5. Mechanism of Action
MOTS-c is believed to influence mitochondrial signaling pathways involved in metabolic regulation, glucose utilization, stress adaptation, and exercise-associated cellular responses.
Potential downstream effects discussed in research include:
- Improved insulin sensitivity signaling
- Enhanced metabolic flexibility
- Exercise adaptation support
- Cellular stress response modulation
- Potential mitochondrial efficiency improvements
The compound is often discussed as an “exercise mimetic” within longevity and metabolic research communities.
6. Potential Benefits
- Potential metabolic support
- Improved exercise tolerance
- Enhanced insulin sensitivity signaling
- Possible body composition improvements
- Potential mitochondrial support
- Theoretical longevity-associated benefits
7. Potential Risks / Side Effects
Experimental
- Limited long-term human safety data
- Injection site irritation
- Fatigue
- Nausea
- Unknown long-term mitochondrial effects
- Potential metabolic dysregulation concerns
8. Half-Life
MOTS-c is believed to have a relatively short circulating plasma half-life.
However, proposed downstream metabolic signaling effects may persist beyond detectable circulation.
9. Storage Information
- Store refrigerated before and after reconstitution
- Protect from direct light exposure
- Avoid repeated freeze-thaw cycles
- Do not shake vigorously after reconstitution
- Maintain sterile handling practices during preparation
10. Contraindications / Warnings
- Pregnancy or breastfeeding
- Severe metabolic disorders
- Uncontrolled diabetes
- Known hypersensitivity to peptide compounds
11. Research References
- PubMed
- NIH Publications
- Mitochondrial signaling literature
- Peer-reviewed metabolic and longevity journals
CKF Tide Tables 